Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD

Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD
Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD: Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD
Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD: Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD
Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD: Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD
Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD: Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD
Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD: Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD
Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD: Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD
Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD: Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD
Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD: Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD
Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD: Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD
Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD: Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD
Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD: Patterns Studied for Alcohol Intake, Outcomes in Patients With CVD

HealthDay News — Among individuals with cardiovascular disease, alcohol consumption is associated with all-cause and cardiovascular mortality and cardiovascular events in a J-shaped manner relative to nondrinkers, according to research published online July 27 in BMC Medicine.

Chengyi Ding, from University College London, and colleagues assessed alcohol consumption with respect to all-cause mortality, cardiovascular mortality, and subsequent cardiovascular events in an analysis of 14,386 patients with previous myocardial infarction, angina, or stroke from the U.K. Biobank Study (1,640 deaths; 2,950 subsequent events); 2,802 patients from the Health Survey for England (1,257 deaths); and three waves of the Scottish Health Survey. This was augmented with findings from 12 published studies, including data on 31,235 patients, 5,095 deaths, and 1,414 subsequent events. The combined sample included 48,423 patients.

The researchers found that alcohol consumption was associated with all assessed outcomes in a J-shaped manner relative to current nondrinkers; the risk reduction peaked at 7, 8, and 6 g/day for all-cause mortality, cardiovascular mortality, and cardiovascular events, respectively (relative risks, 0.79, 0.73, and 0.50, respectively) and remained significant up to 62, 50, and 15 g/day, respectively. Reductions in risk among light-to-moderate drinkers were attenuated in the few studies that excluded former drinkers for the nondrinking reference group.

“Our findings suggest that people with CVD may not need to stop drinking in order to prevent additional heart attacks, strokes, or angina, but that they may wish to consider lowering their weekly alcohol intake,” Ding said in a statement.

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Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression

Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression
Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression: Zuranolone Rapidly Decreases Depressive Symptoms Among Women Experiencing Postpartum Depression

Among women with postpartum depression, zuranolone was found during a phase 3, double-blind trial to improve core symptoms of depression and was well tolerated. These findings were published in JAMA Psychiatry.

Women (N=153) with postpartum depression were recruited within 6 months of giving birth at 27 centers in the United States between 2017 and 2018. Participants were randomly assigned in a 1:1 ratio to receive zuranolone 30 mg (n=77) or placebo (n=76) for 2 weeks. Through day 45, patients were assessed with use of the 17-item Hamilton Rating Scale for Depression (HAMD-17).

The mean ages of patients in the zuranolone and placebo groups were 29.3±5.4 and 27.4±5.3 years old, respectively, and 58% and 54% were White. Body mass index (BMI) was 31.1±6 and 30.3±8 kg/m², 21% and 18% used antidepressants, and baseline HAMD-17 total scores were 28.4±2 and 28.8±2 points, respectively.

At day 15, the change from baseline in HAMD-17 scores was -17.8 points among the active treatment cohort and -13.6 points among the placebo group (P =.003). This significant difference was found to be sustained 4 weeks after treatment cessation on day 45 (least-squares mean difference, -4.1; 95% CI, -6.7 to -1.4; P =.003).

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The response rate on day 15 was 72% among the zuranolone and 48% among the placebo cohorts (odds ratio [OR], 2.6; 95% CI, 1.3-5.2; P =.005), and remission rates were 45% and 23%, respectively (OR, 2.5; 95% CI, 1.2-5.2; P =.01).

Stratifying patients into subgroups of age, ethnicity, antidepressant use, BMI, onset of postpartum depression, or family history had no effect on the efficacy of zuranolone compared with placebo.

Adverse events were reported by 60% of the zuranolone and 52% of the placebo recipients. The most frequent adverse events reported by participants receiving active and control treatments were somnolence (15% vs 11%), headache (9% vs 12%), dizziness (8% vs 6%), upper respiratory tract infection (8% vs 1%), and diarrhea (6% vs 3%), respectively.

The longer-term efficacy of zuranolone for the treatment of postpartum depression remains unclear, but there is an ongoing open-label trial to address this question.

The study authors concluded that zuranolone rapidly decreased core symptoms of depression among women experiencing postpartum depression within 6 months of giving birth.

Disclosure: Some study authors declared affiliations with biotech, pharmaceutical, and/or device companies. Please see the original reference for a full list of authors’ disclosures.

Reference

Deligiannidis KM, Meltzer-Brody S, Gunduz-Bruce H, et al. Effect of zuranolone vs placebo in postpartum depression: a randomized clinical trial. JAMA Psychiatry. Published online June 30, 2021.  doi:10.1001/jamapsychiatry.2021.1559

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Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis

Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis
Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis: Nurse-Led Care May Improve Fatigue Management in Patients With Rheumatoid Arthritis

Evidence suggests that nurse-led care is an effective means of reducing fatigue in patients with rheumatoid arthritis (RA), according to findings from a systematic review and meta-analysis published in Journal of Clinical Nursing. Authors of the review advocated for the implementation of nurse-led interventions for the management of patients with RA-associated fatigue.

Nurse-led care refers to a treatment model in which the nurse is a patient’s primary point of contact. Prior studies have shown that nurse-led fatigue management provides a more personalized approach and better addresses psychosocial factors.

To assess the efficacy of nurse-led care in patients with RA-associated fatigue, the study authors conducted a systematic search of the Cochrane Library, Web of Science, PubMed, EBSCOhost/CINAHL Complete, Springer Link, ProQuest, Science Direct, and Ovid databases for randomized clinical trials published between 2003 and 2021. Two separate reviewers evaluated the eligible studies. Methodologic quality and risk for bias were determined using the Quality Assessment Tool for Quantitative Studies and the Cochrane risk of bias tool, respectively. Studies that included fatigue data on a numeric scale were included in the current meta-analysis. Data were pooled and a random-effects model was used to estimate the overall effect of nurse-led care on fatigue reduction in RA.

Of 1445 screened studies, 6 were included in analysis. The pooled cohort included 994 adults with RA. Two studies were conducted in Norway; 2 in England; and 1 each in the United States and Denmark. Across the 6 studies, nurse-led care interventions included in-person visits, consultations, briefings, and clinic appointments. In 3 studies, interventions were implemented by more than 1 nurse. Education sessions were provided to patients in all studies. Psychosocial support was also provided to participants in 3 studies. The duration of each nurse-led care session ranged from 30 minutes to 2 hours. Comparator groups included rheumatologist-led care (n=3 studies), no nurse-led care (n=2), and the clinic support of junior physicians (n=1). Four studies showed that nurse-led care compared with the other study groups significantly reduced fatigue. However, in 2 studies, nurse-led care had no statistically significant impact on fatigue scores.

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In the current meta-analysis, the overall effect of nurse-led care on fatigue was significant (Hedge’s g=-0.18; 95% CI, -0.3 to -0.06; P =.004).

According to these data, nurse-led care appears to have a positive impact on fatigue reduction in patients with RA.

However, sparse data limited the strength of this analysis. Although between-study heterogeneity was low, risk for bias was present in all 6 studies. Due to the nature of the intervention, blinding was not performed in 4 of 6 studies. In addition, sample size was small in 3 studies.

“Nurse-led care is an important strategy that should be considered as a complementary [program] for patients with RA [with] fatigue,” the authors wrote. “[While] there [are] no clear data on the duration and frequency of nurse-led care practices in the fatigue management of patients with RA…nurse-led care is recommended in the fatigue management of patients with RA.”

Overall, further studies are necessary to better understand the impact of nurse-led care in rheumatology settings.

Reference

Sezgin MG, Bektas H. The effect of nurse-led care on fatigue in patients with rheumatoid arthritis: a systematic review and meta-analysis of randomised controlled studies. J Clin Nurs. Published online August 15, 2021. doi:10.1111/jocn.16003

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Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity

Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity
Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity: Polygenic Risk Scores and COPD History Predict COVID-19 Disease Severity

Patients with a higher polygenic risk score (PRS) or history of chronic obstructive pulmonary disease (COPD) were more likely to have severe COVID-19 disease, according to the results of a recent study published in the Annals of the American Thoracic Society.

A polygenic risk score was calculated for study participants by using 112 single nucleotide polymorphisms thought to be related to COVID-19 disease severity. Any history of chronic obstructive pulmonary disease was also factored into overall risk. Logistic regression models were then used to examine associations of genetic risk and/or COPD and COVID-19 disease severity.

Among the 430,582 participants from the UK Biobank study, 712 developed severe COVID-19 during the study. Of these 712, 19.8% had pre-existing COPD. When comparing polygenic risk scores, those with low risk scores had a lower chance of developing severe COVID-19 when compared with either the intermediate or high polygenic risk scores groups.

The study authors wrote, “The PRS which combines multiple risk alleles can be effectively used in screening for high-risk populations of severe COVID-19.” They added, “High genetic risk correlates with a higher risk of severe COVID-19, regardless of pre-existing COPD.”

---

Continue Reading

Reference

Huang QM, Zhang PD, Li ZH, et al. Genetic risk and COPD independently predict the risk of incident severe COVID-19. Ann Am Thorac Soc. Published online July 9, 2021. doi:10.1513/AnnalsATS.202102-171OC

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https://www.google.com/maps?cid=3470181752621453053
https://psychiatrist-austin-tx.business.site/?m=true
https://auramdpsychiatristaustin.tumblr.com/post/663726766300463104
Aura MD | Ashley Toutounchi, MD - Psychiatrist Austin - Online Telepsychiatry Texas
200 Lee Barton Dr #100, Austin, TX 78704, United States
https://auramd.com/locations/texas/austin
(512) 764-9858
767V+C7 Austin, Texas, United States
https://www.google.com/maps?cid=3470181752621453053
https://psychiatrist-austin-tx.business.site/?m=true
https://auramdpsychiatristaustin.tumblr.com/post/663741857413611520
Aura MD | Ashley Toutounchi, MD - Psychiatrist Austin - Online Telepsychiatry Texas
200 Lee Barton Dr #100, Austin, TX 78704, United States
https://auramd.com/locations/texas/austin
(512) 764-9858
767V+C7 Austin, Texas, United States
https://www.google.com/maps?cid=3470181752621453053
https://psychiatrist-austin-tx.business.site/?m=true